cordially invites you to attend an amazing afternoon
Chief Legal Correspondent for ABC and Author of Man Down
Monday, March 5, 2018
The Treetop Ballroom at Jungle Island
1111 Parrot Jungle Trail
10:00 AM - 11:30 A.M.
1:30 PM – 3:00 P.M.
LUNCH WITH DAN BEGINS PROMPTLY AT NOON
All Proceeds donated to the
Margaux Renee Grossman Research Fund
at Memorial Sloan-Kettering Cancer Center
Complimentary Parking included.
Women Are Better Than Men Sponsor
Includes One Premier Seat
It's About Time Sponsor
Includes 4 Premier Seats
Proof Beyond A Reasonable Doubt Sponsor
Includes 6 PREMIER Seats
and a Full Page Ad in our Tribute Booklet
Women Are Far Better Than Men Sponsor
Includes 10 PREMIER Seats
and a Full Page Ad in our Tribute Booklet
Please purchase your Luncheon 2018 tickets using the secure PayPal button below.
A new discovery at Boston Children’s Hospital brings new hope in the fight against Ewing’s sarcoma, as reported at ScienceDaily. Their summary:
“Researchers have found that Ewing sarcoma cells die if an enzyme called CDK12 is knocked out genetically or chemically inhibited. What’s more, when a CDK12 inhibitor is combined with another drug, called a PARP inhibitor, the two drugs double down to deliver a lethal punch to Ewing sarcoma cells.”
Read the full article on ScienceDaily.com for more information.
This has been another exciting and productive year for research in the sarcomas of children and young adults. Let me highlight four major advances and approaches:
1. We have successfully begun a clinical trial of a radically new approach for the treatment of Ewing sarcoma. Dr. Jeffrey Toretsky has developed a compound which completely stops the growth of Ewing sarcoma in the laboratory. In collaboration with colleagues at MD Anderson and UCLA, we have now enrolled 20 patients in a clinical trial to test this compound in children. We are required by the FDA to proceed slowly to prove that it is safe, but we are now reaching the doses that should have a beneficial effect. We are extremely excited about the possibilities for this line of investigation.
2. We have designed a trial for newly diagnosed patients with Ewing sarcoma that incorporates into our initial therapy two new drugs that achieved a high rate of response in patients with recurrent Ewing sarcoma. Our preliminary data are showing that we have increased the probability for cure for children who present without metastatic disease to 95%, which is a dramatic increase over our historical results of 70%.
3. Working with MSKCC’s Dr. Nai-Kong Cheung and his colleagues, we have developed an antibiotic that can help to control metastases of osteosarcoma, the most common form of primary bone cancer in children and young adults. We have treated over 40 children and young adults with this antibody. The results are sufficiently exciting and a company has agreed to sponsor a Phase III front line trial for patients with osteosarcoma which will be led by MSKCC but will include the participation of partners at other major cancer centers around the US.
4. Dr. Neerav Shukla, another MSKCC pediatric oncologist, has focused research on the genomics of pediatric tumors including Ewing sarcoma. He has developed an extremely sensitive assay to test for the presence of a DNA sequence unique to the tumor in 40 patients with Ewing sarcoma and it has shown exciting promise as an early warning detector for tumor recurrence before it becomes detectible by scans or X-rays. His exciting work has been published in the Journal of Precision Oncology and led to a leadership role in the Children’s Oncology Group to extend this work nationwide.
So to all Margaux’s Miracle Foundation supporters, I urge you to help us continue these vital efforts to eradicate these deadly and rare cancers. I look forward to seeing you on March 5th.
Paul A. Meyers, MD
Professor of Pediatrics
Weill Cornell Medical College
Robbins Family Chair in Pediatrics
Vice Chair, Department of Pediatrics
Memorial Sloan-Kettering Cancer Center
1275 York Ave
New York, NY 10065
Many thanks to the brilliant writer, speaker, and our Woman of the Year, Gloria Steinem, to Dr. Paul Meyers for discussing the latest developments at Memorial Sloan-Kettering, and to our student guests from the University of Miami.
Many thanks to the Capitol Steps for a laugh-out-loud performance, and to Dr. Paul Meyers and Dr. Leonard Kalman for discussing the new partnership between Memorial Sloan-Kettering and Baptist Health. Finally, a big congratulations to the Woman of the Year, Carole Masington.
“In the heat of the election season, this hilarious ensemble takes on the political fervor. No matter who or what is in the headlines, you can bet “THE CAPITOL STEPS” will tackle both sides of the political spectrum and all things equally foolish. What more would you expect from the group that puts the “MOCK” in Democracy?!”
A heartfelt thanks to our friends at the Unity School, who each performed over 100 hours of Community Service in honor of Margaux. These 8 students combined performed 1,525.5 hours of service, with seventy of the school’s students performing a grand 3,260.5 hours of service, all in Margaux’s name. We are very grateful for all of your volunteering efforts!
Many thanks to Carl Hiaasen for his witty discussion about the oddities of Florida, to Paul Levine for his hilarious introduction, and to Dr. Meyers for his insights into the field of medicine. Finally, a well-deserved congratulations to Woman of the Year and our event decorator, Nancy Gilbert.
Join us for a fabulous day of shopping and a special discussion with author Carl Hiaasen. Click below to purchase tickets through PayPal.